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Dr. Sarah Bailey
Research Fellow in Primary Care at the University of Exeter
June 13, 2017 · 4,351 Reads

A simple blood count could help diagnose cancer earlier

In Short: Having a high blood platelet count is a strong predictor of cancer and should be urgently investigated to save lives, according to a large-scale study.

Background

Cancer is one of the greatest health concerns in the developed world, with approximately 14 million new cases per year across the globe. In the UK, cancer survival is poorer than in the US and in many other European countries. Much research is focussed on finding out why and developing strategies to improve cancer outcomes in the UK.

Diagnosing cancer earlier is a key strategy to improving survival for patients.

When cancer is diagnosed at an earlier stage, it is easier to treat, and patients are likely to survive for longer. For example, 50–70% of patients with stage I lung cancer survive for five years after diagnosis, whereas for stage IV, only 2–10% survive for as long.

We investigated the platelet count as a potential diagnostic marker of cancer.

Platelets are small cells in the blood which are involved in the blood clotting process and in immune response.

A normal platelet count is 150–400 billion platelets per litre of blood; anything over 400 is a raised platelet count, known as thrombocytosis. The platelet count is measured as part of a routine blood test.

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Discovery

The study found that thrombocytosis is an important risk marker of cancer. Thrombocytosis is a disorder in which your body produces too many platelets. We compared the proportion of new cancer cases in two groups of patients: those with thrombocytosis (raised platelet count) and those with a normal platelet count. Results indicated that 11% of men and 6% of women with thrombocytosis were diagnosed with cancer, as opposed to 4% of men and 2% of women with a normal platelet count. This means that the risk of cancer was three times higher in patients with thrombocytosis, compared to those with a normal platelet count.

The future

These figures are exciting as they show that thrombocytosis could be used by doctors to identify patients to send for further investigation for cancer earlier; perhaps before other symptoms begin. In the study, a third of lung and colorectal cancer patients with thrombocytosis had no other ‘alarm’ symptoms that would have prompted cancer investigations in the year before they were diagnosed.

If thrombocytosis was recognised as a risk marker of cancer, it is likely that a third of lung cancer patients would have their diagnosis made earlier — which could make the difference in longer survival.

Research Article: Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data. British Journal of General Practice. 67 (659): e405-e413.

Editors note: This is a correlation study and should not be confused with causation. This article was written by Dr. Sarah Bailey, the first author of this study. Dr. Sarah Bailey is a research fellow at the University of Exeter Medical School, UK.

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Mia
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Mia

So I really don’t understand how this works. I worked at a daycare center in August 2017 then started getting real sick. I had an upper respiratory infection and all kinds of other viruses. Then I went to the doctor in March of 2018 she was concerned that my vitamin D levels were low 10 points low. Then she tells me my platelet count is 456 so I started taking vitamin D now I go to get another blood test and its 469. I decided not to take vitamin D anymore and hope that it goes down! I am on… Read more »

Kita
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Kita

I too am disgusted with the information I’m getting from my doctor who acts so nonchalant about everything. I have told him about how tired I am alllllll of the time. i had blood work done a few weeks back and the BUN test level came back low so I went to my doctor and he had more blood test ran. I had to call him back after 7 days due to looking online for results which is now saying my platelets are 468. He prescribed me vitamin d pills because my level was 19.7 and says everything is fine.… Read more »

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[…] Reference: British Journal of General Practice […]

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